I've been playing with it on 2 machines so far, an Asus EEE PC 1000h and a Dell Inspiron 1520.
Both machines run it quite well, I was in fact a little suprised at how well the Asus did run it. Eset Smart Security runs fine on it for anti-virus/firewall and I have played a few games on the 1520 with no problems. I have encountered 2 programs that will not work, one is Daemon Tools, and I believe from what I've read that it is the Virtual SCSI driver that does not work rather then Daemon tools itself, I'm using Slysoft's freebie virtual drive program for the time being. My main issue right now is that Real VNC viewer does not seem to work, I have the Enterprise version for work and I haven't tried the server but the viewer just comes back with an error message when trying to launch it.
I also miss the quicklaunch bar as I found it extremely handy, I suppose I'll live though, other then that so far I like it well enough.