Well, how old is that MB, first off? If the mobo supports 48-bit LBA, then it will support that drive. Otherwise, there's two limitations to keep in mind:
1) If it's a PII-era mobo, it probably is limited to 36 GB.
2) If it's about 3 or more years old, it's probably limited to 137 GB.
Check for BIOS upgrades too, because sometimes 48-bit LBA support can be added by the manufacturer.
Additionally, of course, there's Windows XP support. You need at least SP1 to support drives larger than 137 GB. Of course, SP2 is ideal for other reasons, especially for security purposes. If you're running Windows 2000, I think you need, at least, SP4.
Ep, glad to see you come back and tidy up...did want to ask a one day favor, I want to enhance my resume , was hoping you could make me administrator for a day, if so, take me right off since I won't be here to do anything, and don't know the slightest about the board, but it would be nice putting "served administrator osnn", if can do, THANKS