Originally posted by ming
If possible, leave the side of your case open. Lets more heat out.
In certain case/fan configurations this can reduce the efficiency of
air-cooling as the air isn't being forced over the hot-spots.
There is no point putting thought into the cooling process by carefully selecting case fans,
and their positioning if only to negate the desired effect by opening up the case side.
Also any drive cooling being performed by the fan at the
front/base will be lost as the air
is not being circulated around the device with any degree of pressure.
If you're gonna have 2 fans....put 1 in the front of yer case at the
bottom sucking air in, and put another at the top at the rear.
This will help pull cool air in and expel the heated air (hot air rises, right?.....

.)
Alternatively put both at the back, but this won't help with drive cooling
if your drives are at the front. (most are)