OK this problem is one I thought would clear up with a reboot, but it has not. First let me say my AV is up to date, enabled, I am behind a router and have run Adaware and Spybot.... Now the problem is hard to describe - but some places I can usually left click I am no longer able! A good example is on my Start Menu! This can be annoying to say the least - and means I have not so far been able to get to System Restore! Even the "run" is on the start menu! Also only some of the IE links are working - and none of my quick launch buttons will function! Even right click is not working for me off the systray! It feels like the machine is in serious trouble - yet this IE window is working and allowing me to post (so I know it is not hardware or anything). Seems/feels like a being hijacked or infected issue - yet none found and no other symptoms.... I am also unable to click on my Serence Klipfoio links - going to post this and experiment some more as to what I can and cannot do - may come back to edit. [EDIT] Oh yes and none of my pull-downs will work! Believe me this really starts to challege you even when you know all the keyboard shortcuts! And three finger salute does nothing too - well just makes the noise for no can do - seems any action to bring up a window or start a task is doomed.... About to try safe mode now... I am highly suspicious of AlphaV which I am running in startup to put system clock on my start button... just tried soft reset and got horrible wheezy noise generated.... going to have to pull the plug on my baby to get to safe mode![/EDIT] I have powered down and rebooted - from scratch - problem did not seem to be there at first, but has come back. Any ideas before I go into "safe mode" and any suggestions for best course of action when there? Is Restore best first action?