Erm, inspite of the Devious nature of the Application i will show you the way..
all you need to do is NOT install any 3-rd party software, the simplist way is to convert your drive to ntfs
i.e Convert X: /FS:NTFS
BTW you need Admin Equivilent access
Then, you go to Folder options and uncheck "Simple File sharing" to get to the DACL (Discretionary Access Control List) (and who said being an MCP is a bad thing?)
and then REMOVE every user from the DACL, that's the permissions tab under security under the HD's Properties
and just add your username will full rights, then it's unrestriced access to you but restricted access to any other user..
and for extra protection turn back on the "Simple file sharing" so people can't waltz in and undo all your hard work
BTW, it may help if they are not administrators too or they may just take ownership of the hard-drive and all your work will be for nought.
hope this helps