AdShield is the muts nuts. It's FREE and all you do is drag and drop the ads or right click on the pop up and add it to your list and from then on it wont pop up or load the ad. It rules go here for more details
i use analog x pow!, and it works great. the only thing you have to do is put it in your startup folder so it loads up everytime you start your computer. just use startup control panel, which can be found on download.com.