If you have another comp/system NTFS enabled (NT4.0 SP6a or higher) you could mount that hard disk to that working system and do what you need.
If not you should use Khayman advice: boot to XP recovery console by pressing F8 right before startup screen (if you have it previously installed) or by using WindowsXP CD.
Only consider that a repair install just checks integrity and version of system files and will not revert back any harmful changes to your system. You use repair install when a boot file is missing or corrupted.
Since you need to delete a file, the recovery console command line is what you need (it lets you handle NTFS volumes just like dos with specific commands).
But if that damned file comes after a bad driver or service installation, its deletion will likely not fix your system... in this case you need to disable that specific driver or service to neutralize a previous harmful installation.
By the way, have you tried booting to the last known good configuration?