I gotta agree with Sazar, definitely worth trying to do something with those wires.
Also, the airflow from the case fans is designed to work with the side on and will cool better with the side on. If you can get a side on it, it'll improve air flow. The other thing to bear in mind is if you have to many fans blowing out and not enough in you'll get low pressure in your case which won't cool your components as efficiently.
i agree; cable management should be your next step. which includes remounting those harddrive as far forward as you can and routing all power drive/card power cabling together and secured down to the other side panel, along the motherboard. easier said than done, i know.. but i would call it necessary.
i'm helping a friend build an sli system and this is what i've decided would be a good setup...
i'm using one of the LeadTek 6800GT's. AGP version though. quite the nice card. 58C on idle, probably peaks at around 62-64. 42C ambient temp. Runs just about every game you can think of like a dream. Can't wait to test in Half-Life 2's Lost Coast...... or Garry's Mod v8, whichever comes first.