MS stores program setup information in the registry (that's what it's for) but spyware and malware can highjack the settings and point them to something else. Like making your start page "XXX-PORN_INC".
A removal tool may take out the new setting, but then it doesn't know where it used to point to so it may set it to some default like "MSN" instead, or leave it blank.
I don't have any listing like that in my registry under "HKEY_USERS\" they all start with "S" and a bunch of numbers.
Ep, glad to see you come back and tidy up...did want to ask a one day favor, I want to enhance my resume , was hoping you could make me administrator for a day, if so, take me right off since I won't be here to do anything, and don't know the slightest about the board, but it would be nice putting "served administrator osnn", if can do, THANKS