no affect whatsoever. look at servers across the world (including this one); they stay online for months straight without being rebooted. one of my servers has been online for 120 straight days without a reboot (and that's nothing).
you put me to shame ive got to turn my computer off every night cuz parents dont want me wasting electric that they pay for Tehe but ill leave it on for downloads but see my computers in my room and its like a bloody concorde at night
have you every noticed that your pc always seems louder at night *Weird*
i got a winner in the category for PC at work they use a computer to control the sprinkler systems its been on for like 3 years
i can hear that the fans are beginning to die and its got burn marks on the screen the amount of times ive been tempted to hit that power button i might do it on my last day tehe
but now im gonna put it into a doze stand-by mode and beat you buggers i gotta be good at something