Yeah its real fun, I have it on the PS3 and I have played a couple of hours. I have already been to a strip club and been invited "upstairs" as part of the story. I have the NZ copy that was censored because of Australia do the 'strippers" in the other uncensored versions wear bikinis as well?
I installed Vista with a Quadcore and 8Gb of ram no probs, I would advise to make sure you have the correct power cables plugged in, I had a problem with my second GFX card that I hadn't remembered to plug in one of the connectors, other than that I would say to leave the indexing on once you...
I'm having a little trouble with Hellgate London, but that sounds like its more their problem than Vistas, it is nice to see on the screen that it says DX10 x64, I've been waiting a long time for that.
Now that is what you call brand loyalty, its the same reason why I buy Gigabyte and Seagate and also still buy my parts from the same guy as I purchased my very first parts from, they treat you well and we keep buying from them :)