I've tried aquiring with Photoshop 6, 7 and ACDSee, and I've used the program that came with it. As for the memory suggestion, thats what I thought lastnight when I was using it. I kept Task Manager open and watched the memory and CPU usage looking for clues, but all seemed fine. I remember the errors mentioning something about being in use or maybe something to do with the twain. I've waited a while after certain scans didnt seem to work to let it finish, but it never does. The scanner sounds like it goes through the normal motions, but the times it locks up it doesnt actually scan anything.