Because Micrsoft decide to remove OneCare from Vista there is no longer any protection against virus, therefore I thought I would try McAfee VirusScan Plus 2007 (this walways bugs me when they bring out products called 2007 when we are not even out of 2006 yet) purchased downloaded and working like a dream with Vista not problems whatsoever... Purchased from the US much cheaper. cost me £21.00 instead of £39.99 in the UK... I love purchasing stuff from the States it' much cheaper and the TAX and VAT is cheaper as well. So if you need a AV then McAfee VirusScan Plus 2007 works fine with Vista.